Capecitabine

Common name: Capecitabine

Commodity name: Xeloda

Chemical name: 5'-Deoxy-5-Fluoro-N-[(Pentyloxy)Carbonyl]Cytidine

Molecular formula: C15H22O6N3F

Cas No.: 154361-50-9

Molecular weight:359.35

Assay content? : 99.0%min

Moisture content: 1.0% max

Related matter?: 0.5% max

Capecitabine (INN)?(Xeloda, Roche) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil.