Nisin

C. A. S. Number 1414 - 45 -5 Chemical formula C143H230N42O37S7 Structural formula see below Formula weight 3354.12 DESCRIPTION Nisin concentrate is a white, micronized, spray-dried powder. Nisin concentrate is stable at ambient temperatures. Both purified nisin and nisin concentrate are stable to heating under acid conditions, and will withstand 121o for 30 min at pH 2.0 and 15 min at pH 3.0. Nisin is less stable at higher pH values; Heating at 121o in buffer for 15 min. Results in the following percentage decreases in activity: PH 4.0-29%, pH 5.0-69%, pH 6-86%, pH 7.0-99.7%. FUNCTIONAL USES Antimicrobial preservative CHARACTERISTICS IDENTIFICATION Solubility Passes testSee description under TESTS Melting point None. Chars on heating Differentiation from other antibiotics Passes testSee description under TESTS PURITY Loss on drying Not more than 3.0% (102-103o, to constant weight) Arsenic Not more than 1 mg/kg (Method II)Test a sample of 3 g Heavy metals Not more than 2 mg/kgTest 10 g of the sample