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Treatment Studies suggest that willow bark may be useful for the following conditions: Headache Willow bark has been shown to relieve headaches and there is some evidence that it is less likely to cause the same gastrointestinal side effects that other pain relievers, such as ibuprofen and other nonsteroidal anti-inflammatory drugs, do. However, studies have not shown this conclusively, and people who are prone to stomach upset may want to avoid willow bark. Large-scale studies are needed to fully determine the safety and effectiveness of willow bark for chronic or recurrent headaches. Low back pain Willow bark appears to be effective for back pain. In a well-designed study of nearly 200 people with low back pain, those who received willow bark experienced a significant improvement in pain compared to those who received placebo. People who received higher doses of willow bark (240 mg salicin) had more significant pain relief than those who received low doses (120 mg salicin). Osteoarthritis Several studies have shown that willow is more effective at reducing pain from osteoarthritis than placebo. In a small study of people with osteoarthritis of the neck or lower back, those who received willow bark experienced significant improvement in symptoms compared to those who received placebo. A similar study of 78 patients hospitalized with osteoarthritis of the knee or hip joint found that patients who received willow bark experienced significant pain relief compared to those who received placebo