Sesamin
Catalog No. 70310
CAS Registry No: 607-80-7
Formal Name: [1S-(1α,3aα,4α,6aα)]-5,5?(tetrahydro-1H,3Hfuro[
3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole
MF: C20H18O6
FW: 354.4
Purity: ≥ 95%
Stability: ≥ 1 year at -20癈
Supplied as: A crystalline solid
UV/Vis: λmax: 235, 286 nm
Laboratory Procedure
For long term storage, we suggest that sesamin be stored as supplied at -20癈. It will be stable for at least one year.
Sesamin is supplied as a crystalline solid. A stock solution may be made by dissolving the sesamin in an organic
solvent purged with an inert gas. Sesamin is soluble in organic solvents such as ethanol, DMSO, and dimethyl
formamide. The solubility of sesamin in these solvents is 0.5, 12, and 33 mg/ml, respectively. Sesamin will be stable
for at least six months in these solvents if stored at -20癈.
Sesamin is sparingly soluble in aqueous buffers. Further dilutions of the stock solution into aqueous buffers or
isotonic saline should be made prior to performing biological experiments. For maximum solubility in aqueous
buffers, sesamin should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Sesamin has a
solubility of 50 μg/ml in a 1:10 solution of DMF:PBS (pH 7.2) using this method. Store aqueous solutions of sesamin
on ice and use within 12 hours of preparation. Although the aqueous solutions of sesamin may be stable for more than
12 hours, we strongly recommend using a fresh preparation each day.
Sesamin is a non-competitive inhibitor of Δ5-desaturase. It inhibits the conversion of dihomo-γ-linolenic acid to
arachidonic acid with a Ki value of 155 μM in rat liver microsomes.1