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Banff Green Technologies, Inc.

China Manufacturer with main products: Diethyl Fluoromalonate, Dimethyl Fluoromalonate, D Ethyl Ester, L Base, Florfenicol, Chloramphenicol

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Dimethyl fluoromalonate,CAS 344-14-9

FOB Price: 30.00 - 40.00 USD/Kilogram
Supply Ability: 300 Ton/Tons per Year
Payment Terms: L/C, T/T, Other, PAYPAL, Credit Card
In Stock
Export Markets: North America, South America, Eastern Europe, Southeast Asia, Africa, Oceania, Mid East, Eastern Asia, Western Europe
Packaging Details: 200kg/drum

Quick Details

  • Appearance: Colorless to pale yellow solid or liquid
  • Purity: 98%(Min,GC)
  • Type: Agrochemical Intermediates,Dyestuff Intermediates,Pharmaceutical Intermediates
  • MF: C5H7FO4
  • Other Names: 2-fluoro-malonic acid dimethyl easter
  • CAS No.: 344-14-9

Specifications

What is Dimethyl fluoromalonatenate?

Dimethyl fluoromalonatenate, CAS number 344-14-9, is an organic intermediate widely used in the fields of pharmaceuticals, agricultural chemicals, materials, dyestuff, industrial additives, etc. It is also known as 2-fluoro-malonic acid dimethyl easter; 2-fluoro-4-methoxyacetoacetic acid methyl ester; Butyric acid, 2-fluoro-3-oxo-4-methoxy-, methyl ester; Dimethyl 2-fluoromalonate; Methyl 2-fluoro-4-methoxyacetoacetate; Fluoro-malonicaciddimethylester, etc.

 

Key applications of Dimethyl fluoromalonatenate

The already known key applications of Dimethyl fluoromalonatenate include: used as pharmaceutical intermediate, in synthesizing fungicides, special materials, dyestuff, enzyme inhibitors, fluoride-containing amino acids, fluoride-containing Chalcone, sedative, etc. The research and industrialization of Dimethyl fluoromalonatenate is still at the beginning stage, and more applications will be explored in the future. 

 

Dimethyl fluoromalonatenate as pharmaceutical intermediate

Dimethyl fluoromalonatenate has been shown to be a valuable intermediate in the synthesis of alpha-fluoroalkanoic acids, including y-fluoroglutamic acid. It is also an intermediate for 5-Fluoropyrimidine (CAS 675-21-8) compounds, which shows good bioactivities for anti-cancer, antibacterial effects.

 

Dimethyl fluoromalonatenate used in agricultural chemical industry

Dimethyl fluoromalonatenate is an important intermediate for the synthesis of environment-friendly fungicide Fluoxastrobin developed by Bayer CropScience in 2005. Fluoxastrobin, commonly used  in Fandango, Fortix, Scenic, DISARM, EVITO, and HEC 480 SC (trade names), is a new strobilurin fungicide active ingredient for the control of fungal diseases such as early blight, late blight, leaf spots, leaf rust, and Rhizoctonia solani. 

 

Dimethyl fluoromalonatenate for special materials

New functional fluorinated materials are rapidly emerging to meet the demanding requirements of advanced applications in fields as diverse as sensing, catalysis and environmental protection due to its excellent prosperities such as chemical resistance, heat endurance, dielectricity, noninflammability, non-stick performance and wear-resistance. AS per Journal of Materials Chemistry, fluororesin, fluoroelastomers, and fluorosilicone (FRS) are very popular fluoride-containing materials widely used in the fields of photoelectrons, fiber optic, etc. Dimethyl fluoromalonatenate can be used as the starting material for many of these specialty materials.

 

Dimethyl fluoromalonatenate in synthesizing 4,5,6-Trifluoropyrimidine and dyestuff

More information is to be updated for the mechanism of action of Dimethyl fluoromalonatenate for the preparation of 4,5,6-Trifluoropyrimidine (CAS 17573-78-3). 4,5,6-Trifluoropyrimidine is an important pesticide intermediate and it is also applied as an intermediate dye industry. 

 

Dimethyl fluoromalonatenate in preparing enzyme inhibitors

According to Wikipedia, fluoride salts are commonly used in biological assay processing to inhibit the activity of phosphatases, such as serine/threoninephosphatases. Fluoride mimics the nucleophilic hydroxide ion in these enzymes' active sites.Beryllium fluoride and aluminium fluoride are also used as phosphatase inhibitors, since these compounds are structural mimics of the phosphate group and can act as analogues of the transition state of the reaction. Dimethyl fluoromalonatenate can be used to various synthesize enzyme inhibitors.

 

Dimethyl fluoromalonatenate can also be used to prepare fluoride-containing amino acids, fluoride-containing Chalcone, fluorotetrahydroquinolines, and sedative areas. 

 

Our advantages:

 

Environmental friendly and risk free

Our novel manufacturing process is much more environmental friendly than the traditional process. The traditional process emits HF which is extremely toxic and corrosive and a mixture of methylbenzene and triethylamine which are also toxic and difficult to contain. In contrast, our process does not involve any of these materials. Thus, our wastes can be easily treated and reach the emission standard.

 

Higher purity

Our Dimethyl fluoromalonatenate can reach as high as 99% purity (by GC), and is the highest assay that is commercially available. The common purity of Dimethyl fluoromalonatenate on the market is about 90% and it is difficult to further purify.

 

Bulk stock

As Dimethyl fluoromalonatenate is one of Banff's most important products, a large stock is available all year round.

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