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Shaanxi Lyphar Biotech Co., Ltd.

China Manufacturer with main products: Plant Extract, API(Active Pharmaceutical Ingredient), Sex Enhancer, Lab Fine Chemical

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Top Quality Dipyridamole Powder

FOB Price: 325.00 - 380.00 USD/Gram
Supply Ability: 500 Kilogram/Kilograms per Month
Shipping: 3 workingdays after receive payment
Payment Terms: L/C, T/T, Western Union, MoneyGram
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Export Markets: North America, Eastern Europe, Mid East, Eastern Asia, Western Europe
Place of Origin: Shaanxi in China
Packaging Details: 1kg: Packed with aluminium bags with ziplock bags inside 25kg: Packed with paper drum with double

Quick Details

  • Purity: 99%
  • Model Number: Lyph-Dipyridamole
  • Brand Name: Lyphar
  • Usage: Animal Pharmaceuticals
  • Grade Standard: Medicine Grade
  • Type: Auxiliaries and Other Medicinal Chemicals
  • EINECS No.: 200-374-7
  • MF: C24H40N8O4
  • Other Names: Dipyridamole
  • CAS No.: 58-32-2
  • Type: Auxiliaries and Other Medicinal Chemicals
  • CAS No.: 58-32-2
  • EINECS No.: 200-374-7
  • Molecular Formula: C24H40N8O4
  • Molecular weight: 504.6256
  • Purity: 99%
  • Usage: Animal Pharmaceuticals
  • Grade Standard: Medicine Grade
  • Test Method: HPLC
  • solubility: insoluble in water , soluble in acetone and ethanol

Specifications

Product Name: Dipyridamole
CAS NO: 58-32-2
Molecular Formula: C24H40N8O4
Formula Weight: 504.6256
Appearance: ellow crystalline powder
Assay: 99.0% min

Introduction

Dipyridamole is a PDE (phosphodiesterase) inhibitor with antioxidant properties. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis.
Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.
 
Application

1. Dipyridamole has been shown to lower pulmonary hypertension without significant drop of systemic blood pressure
2. It inhibits formation of pro-inflammatory cytokines (MCP-1, MMP-9) in vitro and results in reduction of hsCRP in patients.
3. It inhibits proliferation of smooth muscle cells in vivo and has shown to prevent AV-shunt failure in dialysis patients.
4. It increases the release of t-PA from brain microvascular endothelial cells
5. It results in an increase of 13 - HODE and decrease of 12-HETE in the subendothelial matrix (SEM) and reduced thrombogenicity of the SEM.
6. Pretreatment it reduced reperfusion injury in volunteers.
7. It has been shown to increase myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy.
8. It results in a reduction of the number of thrombin and PECAM-1 receptors on platelets in stroke patients.
9. cAMP impairs platelet aggregation and also causes arteriolar smooth muscle relaxation. Chronic therapy did not show significant drop of systemic blood pressure.
10. It inhibits the replication of mengovirus RNA.
 
Specification
 

Appearance Yellow crystals or crystalline powder Yellow crystalline powder
Solubility Practically insoluble in water,
freely soluble in acetone,
soluble in  ethanol,  It dissolves in dilute solution of mineral acids.
Practically insoluble in water, freely soluble in acetone,
soluble in  ethanol,  It
dissolves in dilute solution of mineral acids.
IR-spectrum Complies  with  reference  spectrum Complies  with  reference  spectrum
Related  substances
HPLC(Ph.Eur.2.2.29)
Total  impurities:not more  than 1.00%
 Impurity A:not  more  than 0.50%
 Impurity B:not  more  than 0.50%
 Impurity C:not  more  than 0.50%
 Impurity D:not  more  than 0.20%
 Impurity E:not  more  than 0.20%
Methyl 4- methyl benzenesulfonate: not more than 1 ppm
Total  impurities:0.70%
 Impurity A:0.37%
 Impurity B:0.14%
 Impurity C:0. 02%
 Impurity D:0.04%
 Impurity E:0.02%
Methyl4- methyl benzenesulfonate:
Absence
GC(Ph.Eur.2.2.28) Each other individual impurity:not more than0.10% Each other individual impurity:not more than 0.10%
Chlorides Not  more  than 200ppm Not  more  than 200ppm
Loss  on  drying Not  more  than  0.5% 0.05%
Sulphated  ash Not  more  than  0.1% 0.06%
Assay Between 98.5% and 101.5%
Calculated on anhydrous  basis
99.2%
Bulk density Not more 400ml/100g 286ml

 

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