Ecvv Trade
Sichuan Benepure Pharmaceutical Co., Ltd.

China Manufacturer with main products: Botanical Extracts, Active Pharmaceutical Ingredients, Intermediates, Food Supplement, Food Additives

Home  >Products Catalog > Hesperidin (90%,95%,98%)

Hesperidin (90%,95%,98%)

Related products from verified members






-beta-d-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one; vitamin p

Molecular Formula


Molecular Weight


CAS no.





The flavonoid hesperidin is a flavanone glycoside (glucoside) comprised of the flavanone (a class of flavonoids) hesperitin and the disaccharide rutinose. Hesperidin is the predominant flavonoid in lemons and oranges,. The peel and membranous parts of these fruits have the highest hesperidin concentrations,especially in immature little citrus fruits.Orange juice containing pulp is richer in the flavonoid than that without pulp. Sweet oranges (Citrus sinensis) and tangelos are the richest dietary sources of hesperidin. Hesperidin is classified as a citrus bioflavonoid.

Hesperidin, in combination with a flavone glycoside called diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids. Hesperidin, rutin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P.

Hesperidin is a solid substance with low solubility in water. It is, however, much more soluble in water than its aglyconehesperetin.

Scientific support

Hesperidin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.

Although some studies indicate that hesperidin has antioxidant activity in vivo, others do not demonstrate antioxidant activity in vitro. The possible anti-inflammatory action of hesperidin is probably due to the possible anti-inflammatory action of its aglyconehesperetin. Hesperetin appears to interfere with the metabolism of arachidonic acid as well as with histamine release. Hesperetin appears to inhibit phospholipase A2, lipoxygenase and cyclo-oxygenase. There is evidence that hesperetin inhibits histamine release from mast cells, which would account for the possible anti-allergic activity of hesperidin.

Again, the possible hypolipidemic effect of hesperidin is probably due to hesperetin's possible action in lipid lowering. Hesperetin may reduce plasma cholesterol levels by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, as well as acyl coenzyme A: cholesterol acytransferase (ACAT). Inhibition of these enzymes by hesperetin has been demonstrated in rats fed a high cholesterol diet.

The mechanism of hesperidin's possible vasoprotective action is unclear. Animal studies have shown that hesperidin decreases microvascular permeability. Hesperidin, itself or via hesperetin, may protect endothelial cells from hypoxia by stimulating certain mitochondrial enzymes, such as succinate dehydrogenase.

The mechanism of hesperidin's possible anticarcinogenic action is also unclear. One explanation may be the inhibition of polyamine synthesis. Inhibition of lipoxygenase and cyclo-oxygenase is another possibility.


Hesperidin has demonstrated some ability to favorably affect lipids and to treat some vascular disorders in humans. Other claims made for hesperidin are based on in vitro and animal studies. These include claims that hesperidin is useful in cancer and immune disorders. There are also claims that hesperidin is an anti-allergen and anti-inflammatory agent based on results from animal experiments.

Hesperidin is present in nutritional supplements as vitamin C with bioflavonoids. Typical dose in these products is about 20 mg. Hesperidin is available in hesperidin-complex supplements. Doses for this type of supplement are usually 500 mg to 2 grams daily. In Europe, hesperidin is available for the management of venous insufficiency and hemorrhoids in a combination product with diosmin. A 500-mg dose of this combination product is comprised of 50 mg of hesperidin and 450 mg of diosmin. Dose for this mixed flavonoid product, for the above conditions, is 1 to 3 grams daily. Another flavonoid, hesperidin methyl chalcone, is often marketed in formulations with hesperidin. This is a different flavonoid, and very few studies have been performed using it.


Commercial Hesperidin is obtained by extraction from immature citrus fruit.

Service Process

Service Guarantee

  • Free Service Charge

    ECVV doesn't charge any service fee to Buyers for buying this product.

  • ECVV Supply

    ECVV is responsible for supply, and provides product quality inspection, fund supervision and supply chain services.

  • Product Quality Commitment

    ECVV China Sourcing Agent will assess the reputation and supply ability of the factory and conduct field trips to select the high-quality Chinese factories for buyers.

  • Deposit Service Commitments

    In order to improve the quality of service, ECVV will charge for a 100CNY deposit for the agent purchasing order, and the deposit will be part of subsequent purchasing costs.

    After paying a deposit, if the purchasing order is not completed because of unsatisfied ECVV services, ECVV will refund your deposit.

Hesperidin from this supplier

Hosetail Extract for Healthcare & Pharm    
FOB Price: 1.00-10.00 USD/Kilogram
Min Order: 1 Kilogram
Bulk Sell Dried Red Beet Root Dehydrated Red Beetroot Flakes Granules    
FOB Price: 2240.00-2350.00 USD/Ton
Min Order: 1 Ton
Bromelain, Pineapple Enzyme Pineapple Stems    
FOB Price: 1.00-80.00 USD/Kilogram
Min Order: 1 Kilogram
High Quality Pure Nicotine Factory for Vapor    
FOB Price: 250.00-300.00 USD/Liter
Min Order: 1 Liter
98% Pharmaceutical Reference Standards Magnoflorine 2141-09-5 for Research Use    
FOB Price: 1.00-5.00 USD/Milligram
Min Order: 20 Milligrams

More products from other suppliers

Capnograph KMT-600    
FOB Price: 980.00-1,200.00 USD/Set
Natural Green Tea extract    
FOB Price: 11.00-30.00 USD/Kilogram
Min Order: 25 Kilograms
Seaweed Powder    
Min Order: 20 Ton
Natural Sweetener with No Calorie Stevia Leaf Extract    
FOB Price: 50.00-120.00 USD/Kilogram
Min Order: 1 Kilogram

Can't find a suitable Supplier or product? Entrust ECVV to purchase the well-chosen Chinese products with high cost performance.

Learn More>> Start Safebuy Order

Communicate with Supplier

Sourcing from ECVV
Join Facebook Group